The interaction of chronic marijuana with other drugs of abuse has not been studied in detail. These factors result in a system that uses less energy with fast processes that require less solvent consumption, but that also produces a final product with high purity (Fig. The study identified that in cannabis resin, exposure to light can affect the decarboxylation of THCA and the degradation of THC. It was clear that prolonged high temperatures accentuated the degradation path from THCA to THC and, ultimately, to CBN, resulting in high levels of THC and CBN (Wianowska et al.
Applying sufficient heat to cannabis causes the decarboxylation of delta‐9-tetrahydrocannabinoic acid (THCA) in its active form, THC 46, but, at the same time, the pyrolysis process transforms some contaminants into more toxic forms. THC is predominantly metabolized by phase 1 oxidative metabolism in the liver through the cytochrome P450 (CYP) system, through the isoenzymes CYP2C9, CYP2C19 and CYP3A4 44, 51, of which it is an inducer. It does not shed light on the pharmacological and PE effects of the above-mentioned contaminants; rather, it serves to highlight that substances that are administered together can interact with THC and other cannabinoids in a way that modulates both their pharmacological and clinical effects. Their findings suggest that the addition of cholinergic compounds (nicotinic agonists, muscarinic antagonists and antiacetylcholinesterase substances) is associated with an increase in the cannabimimetic effects of THC.
Isolation of delta9-THCAA from hemp and analytical aspects related to the determination of delta9-THC in cannabis products. This is based on the popular perception that products that are consumed in this way expose the individual to a lower level of polluting particles, in particular to carcinogens 49. Lower THCA concentrations may be associated with occasional use, extended periods, or probable exposure to cannabis (70). Of these, the THC profile is the most documented and a brief summary of its properties is provided for contextual reasons. When using methanol as an extractant, the first set of results indicated that, even at high temperatures, the concentration of THC was lower than that of THCA using the PLE method.
The results showed that the concentration of THCA and CBDA decreases as the amount of nitrogen increases by 69% and 63%, respectively.
